Microwave-assisted domino access to C2-chain functionalized furans from tertiary propargyl vinyl ethers.
نویسندگان
چکیده
Tertiary propargyl vinyl ethers armed with an electron-withdrawing group (amide or ester) at the tertiary propargylic position have been efficiently transformed into trisubstituted C(2)-chain functionalized furans. The metal-free domino transformation involves a microwave-assisted tandem [3,3]-propargyl Claisen rearrangement/5-exo-dig O-cyclization reaction. The manifold can be performed in a one-pot fashion from the primary components (1,2-ketoester/1,2-ketoamide or tertiary propargyl alcohols).
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ورودعنوان ژورنال:
- Organic letters
دوره 13 16 شماره
صفحات -
تاریخ انتشار 2011